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Its a two-pronged approach: fix the mechanical problem and protect the affected nerves

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Valdez et al., 2016), although in KO mice lacking kinesin family member 21B (Kif21B), a microtubule-dependent molecular motor that regulates the engulfment of the Rac1-GEF, ELMO1/DOCK complex and enhances Rac1 activity, was found to have unstable LFS-induced LTD without alterations in HFS-induced LTP at CA1 synapses (Morikawa et al., 2018)